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EP 28
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Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough

Astrophysics
Dark Matter
Alzheimer's
Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a major Alzheimer’s mechanism paper tracing how exercise protects the brain by repairing the blood–brain barrier—with an actionable drug-like path already emerging. Summary Candidate dark galaxy: how Hubble + Euclid stacking and globular clusters reveal an ultra-faint halo that could test missing satellites and the cusp–core problem—and even “fuzzy dark matter” ideas. Exercise → Alzheimer’s mechanism: UCSF traces a liver enzyme (GPLD1) that can’t cross the BBB, yet protects cognition by regulating TNAP at the brain’s vascular interface—plus a small-molecule mimic (SBI-425) that reproduces the effect in mice. Rundown: Rubin Observatory’s real-time alert engine, AI-accelerated magnet discovery, a climate-corrected Easter Island history, and the Boba-Kiki effect… in baby chicks.
Scientific American·

Baby chicks pass the bouba-kiki test challenging a theory of language

Imagine you hear the made-up words "bouba" and "kiki" - which one sounds round and soft, and which sounds sharp and spiky? Most people say "bouba" sounds round and "kiki" sounds sharp. This is called the bouba-kiki effect, and scientists thought it might be special to humans and related to how we developed language. But this study found that baby chickens, just hours after hatching, make the same connections! When they heard "bouba-like" sounds, 80% of the chicks walked toward round, curved shapes rather than spiky ones. This suggests that connecting sounds with shapes isn't learned or uniquely human - it might be a basic way that many animals' brains work, going back hundreds of millions of years in evolution.

bouba-kiki effect
comparative psychology
The Astrophysical Journal Letters·

Candidate Dark Galaxy-2: Validation and Analysis of an Almost Dark Galaxy in the Perseus Cluster

Imagine trying to find a nearly invisible ghost town in space. That's essentially what astronomers did when they discovered CDG-2. This "galaxy" is so faint that it's almost entirely made of dark matter - the mysterious invisible stuff that makes up most of the universe. The only way scientists could spot it was by noticing four very old, dense star clusters (called globular clusters) floating together in space. It's like finding four lighthouses in the fog and realizing there's an almost invisible island underneath them. What makes this discovery special is that CDG-2 is 99.9% dark matter, making it one of the "darkest" objects ever found. Most galaxies are a mix of stars, gas, and dark matter, but this one is almost pure dark matter with just a tiny bit of starlight.

dark galaxies
globular clusters
Cell Genomics·

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature

This discovery could lead to new treatments for age-related memory loss and Alzheimer's disease that don't require physical exercise. Instead of just telling people to exercise more, doctors might eventually be able to give patients the specific liver protein (GPLD1) or drugs that block TNAP to achieve the brain benefits of exercise. This is especially important for elderly or disabled people who cannot exercise regularly but still want to protect their memory and cognitive function.